abstract：:Plastids in plants and algae evolved from the endosymbiotic integration of a cyanobacterium by a heterotrophic eukaryote. New plastids can only emerge through fission; thus, the synchronization of bacterial division with the cell cycle of the eukaryotic host was vital to the origin of phototrophic eukaryotes. Most of ...

journal_title：Journal of cell science

authors： de Vries J,Gould SB

更新日期：2018-01-29 00:00:00

abstract：:Stem cell regeneration is crucial for both cell turnover and tissue healing in multicellular organisms. In Arabidopsis roots, a reduced group of cells known as the quiescent center (QC) act as a cell reservoir for surrounding stem cells during both normal growth and in response to external damage. Although cells of th...

journal_title：Journal of cell science

authors： Lozano-Elena F,Planas-Riverola A,Vilarrasa-Blasi J,Schwab R,Caño-Delgado AI

更新日期：2018-01-29 00:00:00

abstract：:Ca2+ is a second messenger in many physiological and phytopathological processes. Peroxisomes are subcellular compartments with an active oxidative and nitrosative metabolism. Previous studies have demonstrated that peroxisomal nitric oxide (NO) generation is dependent on Ca2+ and calmodulin (CaM). Here, we used Arabi...

journal_title：Journal of cell science

authors： Corpas FJ,Barroso JB

更新日期：2018-01-29 00:00:00

abstract：:Our previous studies of PAWS1 (protein associated with SMAD1; also known as FAM83G) have suggested that this molecule has roles beyond BMP signalling. To investigate these roles, we have used CRISPR/Cas9 to generate PAWS1-knockout U2OS osteosarcoma cells. Here, we show that PAWS1 plays a role in the regulation of the ...

journal_title：Journal of cell science

authors： Cummins TD,Wu KZL,Bozatzi P,Dingwell KS,Macartney TJ,Wood NT,Varghese J,Gourlay R,Campbell DG,Prescott A,Griffis E,Smith JC,Sapkota GP

更新日期：2018-01-10 00:00:00

abstract：:The human Ras superfamily of small GTPases controls essential cellular processes such as gene expression and cell proliferation. As their deregulation is widely associated with human cancer, small GTPases and their regulatory proteins have become increasingly attractive for the development of novel therapeutics. Class...

journal_title：Journal of cell science

authors： Koraïchi F,Gence R,Bouchenot C,Grosjean S,Lajoie-Mazenc I,Favre G,Cabantous S

更新日期：2018-01-08 00:00:00

abstract：:Cytokinesis in many eukaryotes requires a contractile actomyosin ring that is placed at the division site. In fission yeast, which is an attractive organism for the study of cytokinesis, actomyosin ring assembly and contraction requires the myosin II heavy chain Myo2p. Although myo2-E1, a temperature-sensitive mutant ...

journal_title：Journal of cell science

authors： Palani S,Srinivasan R,Zambon P,Kamnev A,Gayathri P,Balasubramanian MK

更新日期：2018-01-04 00:00:00

abstract：:Casein kinase 1 (CK1) plays central roles in various signal transduction pathways and performs many cellular activities. For many years CK1 was thought to act independently of modulatory subunits and in a constitutive manner. Recently, DEAD box RNA helicases, in particular DEAD box RNA helicase 3 X-linked (DDX3X), wer...

journal_title：Journal of cell science

authors： Dolde C,Bischof J,Grüter S,Montada A,Halekotte J,Peifer C,Kalbacher H,Baumann U,Knippschild U,Suter B

更新日期：2018-01-04 00:00:00

abstract：:The small GTPase Arf4 and the Arf GTPase-activating protein (GAP) ASAP1 cooperatively sequester sensory receptor cargo into transport carriers targeted to primary cilia, but the input that drives Arf4 activation in this process remains unknown. Here, we show, by using frog retinas and recombinant human proteins, that ...

journal_title：Journal of cell science

authors： Wang J,Fresquez T,Kandachar V,Deretic D

更新日期：2017-12-01 00:00:00

abstract：:Voltage-gated Ca2+ (CaV) channels couple membrane depolarization to Ca2+ influx, triggering a range of Ca2+-dependent cellular processes. CaV channels are, therefore, crucial in shaping neuronal activity and function, depending on their individual temporal and spatial properties. Furthermore, many neurotransmitters an...

journal_title：Journal of cell science

authors： Mustafá ER,López Soto EJ,Martínez Damonte V,Rodríguez SS,Lipscombe D,Raingo J

更新日期：2017-11-15 00:00:00

abstract：:The centrosome and cilium are organelles with important roles in microtubule organisation, cell division, cell signalling, embryogenesis and tissue homeostasis. The two organelles are mutually exclusive. The centriole/basal body is found at the core of the centrosome (centriole) or at the base of the cilium (basal bod...

journal_title：Journal of cell science

authors： de Saram P,Iqbal A,Murdoch JN,Wilkinson CJ

更新日期：2017-10-01 00:00:00

abstract：:Misfolded endoplasmic reticulum (ER) proteins are dislocated towards the cytosol and degraded by the ubiquitin-proteasome system in a process called ER-associated protein degradation (ERAD). During infection with human cytomegalovirus (HCMV), the viral US2 protein targets HLA class I molecules (HLA-I) for degradation ...

journal_title：Journal of cell science

authors： van de Weijer ML,Schuren ABC,van den Boomen DJH,Mulder A,Claas FHJ,Lehner PJ,Lebbink RJ,Wiertz EJHJ

更新日期：2017-09-01 00:00:00

abstract：:The COPII coat and the small GTPase Sar1 mediate protein export from the endoplasmic reticulum (ER) via specialized domains known as the ER exit sites. The peripheral ER protein Sec16 has been proposed to organize ER exit sites. However, it remains unclear how these molecules drive COPII coat polymerization. Here, we ...

journal_title：Journal of cell science

authors： Iwasaki H,Yorimitsu T,Sato K

更新日期：2017-09-01 00:00:00

abstract：:Our understanding of cells has progressed rapidly in recent years, mainly because of technological advances. Modern technology now allows us to observe molecular processes in living cells with high spatial and temporal resolution. At the same time, we are beginning to compile the molecular parts list of cells. However...

journal_title：Journal of cell science

authors： Alberti S

更新日期：2017-09-01 00:00:00

abstract：:Directed axonal growth depends on correct coordination of the actin and microtubule cytoskeleton in the growth cone. However, despite the relatively large number of proteins implicated in actin-microtubule crosstalk, the mechanisms whereby actin polymerization is coupled to microtubule stabilization and advancement in...

journal_title：Journal of cell science

authors： Szikora S,Földi I,Tóth K,Migh E,Vig A,Bugyi B,Maléth J,Hegyi P,Kaltenecker P,Sanchez-Soriano N,Mihály J

更新日期：2017-08-01 00:00:00

abstract：:Organelles such as neuropeptide-containing dense-core vesicles (DCVs) and mitochondria travel down axons to supply synaptic boutons. DCV distribution among en passant boutons in small axonal arbors is mediated by circulation with bidirectional capture. However, it is not known how organelles are distributed in extensi...

journal_title：Journal of cell science

authors： Tao J,Bulgari D,Deitcher DL,Levitan ES

更新日期：2017-08-01 00:00:00

abstract：:New concepts in cell organization emerged in a medieval castle during a snowy week in January 2017 in the middle of the Austrian Alps. The occasion was the 10th Annaberg EMBO workshop in Goldegg am See; organized by Gabriele Seethaler, Catherine Rabouille and Marino Zerial. There were 95 participants, including many w...

journal_title：Journal of cell science

authors： Teis D,Kukulski W

更新日期：2017-07-15 00:00:00

abstract：:Low-intensity pulsed ultrasound (LIPUS) is a therapy used clinically to promote healing. Using live-cell imaging we show that LIPUS stimulation, acting through integrin-mediated cell-matrix adhesions, rapidly induces Rac1 activation associated with dramatic actin cytoskeleton rearrangements. Our study demonstrates tha...

journal_title：Journal of cell science

authors： Atherton P,Lausecker F,Harrison A,Ballestrem C

更新日期：2017-07-15 00:00:00

abstract：:Mitochondria play essential roles in cellular energy processes, including ATP production, control of reactive oxygen species (ROS) and apoptosis. While mitochondrial function is regulated by the dynamics of fusion and fission, mitochondrial homeostasis remains incompletely understood. Recent studies implicate dynamin-...

journal_title：Journal of cell science

authors： Farmer T,Reinecke JB,Xie S,Bahl K,Naslavsky N,Caplan S

更新日期：2017-07-15 00:00:00

abstract：:Linear chains of five to hundreds of phosphates called polyphosphate are found in organisms ranging from bacteria to humans, but their function is poorly understood. In Dictyostelium discoideum, polyphosphate is used as a secreted signal that inhibits cytokinesis in an autocrine negative feedback loop. To elucidate ho...

journal_title：Journal of cell science

authors： Suess PM,Watson J,Chen W,Gomer RH

更新日期：2017-07-15 00:00:00

abstract：:Proteins of the Wiskott-Aldrich syndrome protein (WASP) family function as nucleation-promoting factors for the ubiquitously expressed Arp2/3 complex, which drives the generation of branched actin filaments. Arp2/3-generated actin regulates diverse cellular processes, including the formation of lamellipodia and filopo...

journal_title：Journal of cell science

authors： Alekhina O,Burstein E,Billadeau DD

更新日期：2017-07-15 00:00:00

abstract：:Maturation of nociceptive neurons depends on changes in transcription factors, ion channels and neuropeptides. Mature nociceptors initiate pain in part by drastically reducing the activation threshold via intracellular sensitization signaling. Whether sensitization signaling also changes during development and aging r...

journal_title：Journal of cell science

authors： Isensee J,Schild C,Schwede F,Hucho T

更新日期：2017-07-01 00:00:00

abstract：:Bone erosion both demands that the osteoclast resorbs bone matrix and moves over the bone surface. It is widely accepted that these two activities alternate, because they are considered mutually exclusive since resorption is believed to involve an immobilizing seal to the bone surface. However, clear real-time observa...

journal_title：Journal of cell science

authors： Søe K,Delaissé JM

更新日期：2017-06-15 00:00:00

abstract：:Deubiquitylating (or deubiquitinating) enzymes (DUBs) are proteases that reverse protein ubiquitylation and therefore modulate the outcome of this post-translational modification. DUBs regulate a variety of intracellular processes, including protein turnover, signalling pathways and the DNA damage response. They have ...

journal_title：Journal of cell science

authors： Leznicki P,Kulathu Y

更新日期：2017-06-15 00:00:00

abstract：:Many pathways dysregulated in prostate cancer are also involved in epithelial differentiation. To better understand prostate tumor initiation, we sought to investigate specific genes and mechanisms required for normal basal to luminal cell differentiation. Utilizing human prostate basal epithelial cells and an in vitr...

journal_title：Journal of cell science

authors： Frank SB,Berger PL,Ljungman M,Miranti CK

更新日期：2017-06-01 00:00:00

abstract：:Centralspindlin, a complex of the kinesin-6-family member MKLP1 and MgcRacGAP (also known as Kif23 and Racgap1, respectively), is required for cytokinesis and cell-cell junctions. During anaphase, Centralspindlin accumulates at overlapping central spindle microtubules and directs contractile ring formation by recruiti...

journal_title：Journal of cell science

authors： Breznau EB,Murt M,Blasius TL,Verhey KJ,Miller AL

更新日期：2017-05-15 00:00:00

abstract：:ADP-ribosylation factors (Arfs) and ADP-ribosylation factor-like proteins (Arls) are highly conserved small GTPases that function as main regulators of vesicular trafficking and cytoskeletal reorganization. Arl1, the first identified member of the large Arl family, is an important regulator of Golgi complex structure ...

journal_title：Journal of cell science

authors： Yu CJ,Lee FJ

更新日期：2017-05-15 00:00:00

abstract：:Centriolar satellites are membrane-less structures that localize and move around the centrosome and cilium complex in a microtubule-dependent manner. They play important roles in centrosome- and cilium-related processes, including protein trafficking to the centrosome and cilium complex, and ciliogenesis, and they are...

journal_title：Journal of cell science

authors： Conkar D,Culfa E,Odabasi E,Rauniyar N,Yates JR 3rd,Firat-Karalar EN

更新日期：2017-04-15 00:00:00

abstract：:Parasite surfaces support multiple functions required for survival within their hosts, and maintenance and functionality of the surface depends on membrane trafficking. To understand the evolutionary history of trypanosomatid trafficking, where multiple lifestyles and mechanisms of host interactions are known, we exam...

journal_title：Journal of cell science

authors： Venkatesh D,Boehm C,Barlow LD,Nankissoor NN,O'Reilly A,Kelly S,Dacks JB,Field MC

更新日期：2017-04-15 00:00:00

abstract：:The immune synapse (IS) is a specialized structure formed at the contact area between T lymphocytes and antigen-presenting cells (APCs) that is essential for the adaptive immune response. Proper T cell activation requires its polarization towards the APC, which is highly dependent on the tubulin cytoskeleton. Microtub...

journal_title：Journal of cell science

authors： Bustos-Morán E,Blas-Rus N,Martin-Cófreces NB,Sánchez-Madrid F

更新日期：2017-04-01 00:00:00

abstract：:Macroautophagy (autophagy) is a highly conserved intracellular degradation system that is essential for homeostasis in eukaryotic cells. Due to the wide variety of the cytoplasmic targets of autophagy, its dysregulation is associated with many diseases in humans, such as neurodegenerative diseases, heart disease and c...

journal_title：Journal of cell science

authors： Nakamura S,Yoshimori T

更新日期：2017-04-01 00:00:00

abstract：:We uncovered a crucial role for the Aurora kinase A (AURKA)-Twist1 axis in promoting epithelial-to-mesenchymal transition (EMT) and chemoresistance in pancreatic cancer. Twist1 is the first EMT-specific target of AURKA that was identified using an innovative screen. AURKA phosphorylates Twist1 at three sites, which re...

journal_title：Journal of cell science

authors： Wang J,Nikhil K,Viccaro K,Chang L,Jacobsen M,Sandusky G,Shah K

更新日期：2017-03-15 00:00:00

abstract：:One of the hallmarks of cancer is the ability of tumor cells to invade surrounding tissues and metastasize. During metastasis, cancer cells degrade the extracellular matrix, which acts as a physical barrier, by developing specialized actin-rich membrane protrusion structures called invadopodia. The formation of invado...

journal_title：Journal of cell science

authors： Goicoechea SM,Zinn A,Awadia SS,Snyder K,Garcia-Mata R

更新日期：2017-03-15 00:00:00

abstract：:In adherent cells, the relevance of a physical mechanotransduction pathway provided by the perinuclear actin cap stress fibers has recently emerged. Here, we investigate the impact of a functional actin cap on the cellular adaptive response to topographical cues and uniaxial cyclic strain. Lmna-deficient fibroblasts a...

journal_title：Journal of cell science

authors： Tamiello C,Halder M,Kamps MA,Baaijens FP,Broers JL,Bouten CV

更新日期：2017-02-15 00:00:00

abstract：:Cell migration is a complex process requiring density and rigidity sensing of the microenvironment to adapt cell migratory speed through focal adhesion and actin cytoskeleton regulation. ICAP-1 (also known as ITGB1BP1), a β1 integrin partner, is essential for ensuring integrin activation cycle and focal adhesion forma...

journal_title：Journal of cell science

authors： Bouin AP,Kyumurkov A,Régent-Kloeckner M,Ribba AS,Faurobert E,Fournier HN,Bourrin-Reynard I,Manet-Dupé S,Oddou C,Balland M,Planus E,Albiges-Rizo C

更新日期：2017-02-01 00:00:00

abstract：:Splice variants of certain genes impact on genetic biodiversity in mammals. The tumor suppressor TP53 gene (encoding p53) plays an important role in the regulation of tumorigenesis in hepatocellular carcinoma (HCC). Δ40p53α is a naturally occurring p53 isoform that lacks the N-terminal transactivation domain, yet litt...

journal_title：Journal of cell science

authors： Ota A,Nakao H,Sawada Y,Karnan S,Wahiduzzaman M,Inoue T,Kobayashi Y,Yamamoto T,Ishii N,Ohashi T,Nakade Y,Sato K,Itoh K,Konishi H,Hosokawa Y,Yoneda M

更新日期：2017-02-01 00:00:00

abstract：:Actin functions in a multitude of cellular processes owing to its ability to polymerize into filaments, which can be further organized into higher-order structures by an array of actin-binding and regulatory proteins. Therefore, research on actin and actin-related functions relies on the visualization of actin structu...

journal_title：Journal of cell science

authors： Melak M,Plessner M,Grosse R

更新日期：2017-02-01 00:00:00

abstract：:Macroautophagy is morphologically characterized by autophagosome formation. Autophagosomes are double-membraned vesicles that sequester cytoplasmic components for further degradation in the lysosome. Basal autophagy is paramount for intracellular quality control in post-mitotic cells but, surprisingly, the number of a...

journal_title：Journal of cell science

authors： Fernandez-Fernandez MR,Ruiz-Garcia D,Martin-Solana E,Chichon FJ,Carrascosa JL,Fernandez JJ

更新日期：2017-01-01 00:00:00

abstract：:Epithelia within tubular organs form and expand lumens. Failure of these processes can result in serious developmental anomalies. Although tight junction assembly is crucial to epithelial polarization, the contribution of specific tight junction proteins to lumenogenesis is undefined. Here, we show that ZO-1 (also kno...

journal_title：Journal of cell science

authors： Odenwald MA,Choi W,Buckley A,Shashikanth N,Joseph NE,Wang Y,Warren MH,Buschmann MM,Pavlyuk R,Hildebrand J,Margolis B,Fanning AS,Turner JR

更新日期：2017-01-01 00:00:00

abstract：:The cytostome-cytopharynx complex is the main site for endocytosis in epimastigotes of Trypanosoma cruzi It consists of an opening at the plasma membrane surface - the cytostome - followed by a membrane invagination - the cytopharynx. In G1/S cells, this structure is associated with two specific sets of microtubules, ...

journal_title：Journal of cell science

authors： Alcantara CL,Vidal JC,de Souza W,Cunha-E-Silva NL

更新日期：2017-01-01 00:00:00

abstract：:Nervous system development and function are tightly regulated by metabolic processes, including the metabolism of lipids such as fatty acids. Mutations in long-chain acyl-CoA synthetase 4 (ACSL4) are associated with non-syndromic intellectual disabilities. We previously reported that Acsl, the Drosophila ortholog of m...

journal_title：Journal of cell science

authors： Huang Y,Huang S,Lam SM,Liu Z,Shui G,Zhang YQ

更新日期：2016-11-01 00:00:00